Elasticity Theory of the B-DNA to S-DNA Transition
نویسندگان
چکیده
منابع مشابه
Theory of sequence-dependent DNA elasticity
The elastic properties of a molecule of duplex DNA are strongly dependent on nucleotide sequence. In the theory developed here the contribution c of the nth base-pair step to the elastic energy is assumed to be given by a function c̃ of six kinematical variables, called tilt, roll, twist, shift, slide, and rise, that describe the relative orientation and displacement of the nth and (n11)th base ...
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DNA has been described as a semiflexible polymer. But DNA is chiral, so its bending Hamiltonian contains nonlinear terms coupling the curvature κ to the torsion τ , leading to an average 〈τ〉 independent of κ, and variance 〈∆τ〉 scaling as 1/κ. We perform atomistic MD simulations of 31 base-pair DNA sequences with explicit solvent, in which “restraints” are imposed to “encourage” the DNA to bend....
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1998
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(98)77774-4